Utilizing Synchrotron-based analytical and Pair Distribution Function Data, Improved Pharma provides an expert assessment of the current status of your polymorph screening activities. These Synchrotron-based studies provide structural knowledge and also analytical information at/near the lowest possible detection limit. Improved Pharma may suggest additional experiments or approaches to determine which form is most stable. Improved Pharma can also use Read more
WEST LAFAYETTE, Ind. (PRWEB)October 15, 2021 Starting Monday, October 18th, Dr. Susan-Bogdanowich-Knipp, President of Ravine Pharmaceuticals and consultant with Improved Pharma, will present “Polymorph Screen of Newly Discovered Salts of Bedaquiline”. The poster (M2142) is part of the Manufacturing and Analytical Characterization – Chemical – Drug Substance Manufacturing and Development – Crystal Structure/Polymorph Screening Read more
WEST LAFAYETTE, Ind. (PRWEB)October 11, 2021 Improved Pharma is pleased to announce a new collaboration with Stephan Parent of Solsta Consulting, LLC. Stephan Parent has more than two decades of solid-state chemistry experience in numerous scientific and management roles. As an expert who specializes in both early and late stage pharmaceutical development and assists Read more
WEST LAFAYETTE, Ind. (PRWEB)October 06, 2021 Improved Pharma is pleased to announce expanded capabilities with the new addition of an in-house Coulometric Karl Fischer titrator equipped with a Stromboli oven sample changer. Understanding the role that water plays on many pharmaceutical drug substances as well as drug products can be critical in the early Read more
Improved Pharma is pleased to announce the addition of Ruba Alajlouni to the team. Ruba brings expertise in regulatory and quality compliance along with hands-on experience in microbiology, cell culture, molecular biology, protein purification, Raman spectroscopy and chemometrics. She started independent consulting work right after getting her second MS degree from Stephen Byrn’s lab Read more
Improved Pharma is pleased to announce an additional open-source publication describing the structures of Bedaquiline maleate salts that is now available to download. Previously, our lab was able to identify promising new benzoate salts of Bedaquiline, a first-in-class drug used in the treatment of tuberculosis. This current publication describes the successfully solved crystal structures obtained from Read more
WEST LAFAYETTE, IND. (PRWEB) APRIL 26, 2021 Improved Pharma is delighted to announce the expansion of its current laboratory to accommodate additional research capabilities. The addition of the newly acquired laboratory facility in the Purdue Kurz Technology Center has effectively doubled the previous laboratory space and will allow for the acquisition of new instrumentation in Read more
Dr, Stephen Byrn, CSO of Improved Pharma, was a key contributor to a recent publication describing the usefulness of mini-tablets in monitoring the dose-response of lapatinib solid amorphous dispersions in juvenile pigs. Juvenile pigs have been well-established as an effective pediatric model. The use of mini-tabs allowed for dose flexibility as the the amount of tablets dosed could Read more
A recent collaboration with our colleagues further advances the field of X-ray pair distribution function analysis applied to the analysis of amorphous solid dispersions. In this paper, we present the results of different polymer:flubendazole drug dispersions exposed to aging conditions. We discovered that if the polymer has ion-base interactions with the drug, the resulting Read more
In February 2021, the FDA issued a guidance aimed at preventing unacceptable levels of nitrosamine impurities in pharmaceutical products. This guidance required a risk assessment to be completed by March 31, 2021. This is because nitrosamines are genotoxic and are classified as possible or probable carcinogens. The guidance also described conditions under which nitrosamines Read more
