Improved Pharma is pleased to announce the open-source publication of research into finding new salts of bedaquiline, an important drug for the treatment of tuberculosis. The drug is currently marketed in the US as the fumarate salt. Our team discovered several new salts, and the crystal structures of two benzoate salts are described in this Read more
WEST LAFAYETTE, IND. (PRWEB) OCTOBER 26, 2020 Interact with us via poster number 924440 and the Advances and Innovation in Formulation Development Rapid Fire session. On Wednesday October 28th, Dr. Pamela Smith, COO of Improved Pharma, will present “Synchrotron-Based Formulation Development” in the Rapid Fire: Formulation and Quality – Chemical session. Those registered for the meeting Read more
Improved Pharma COO Pamela Smith is co-author of a chapter in the latest edition of Specification of Drug Substances and Products: Development and Validation of Analytical Methods. The chapter, Solid-State Characterization – Method Development and Validation, focuses on the key issues that must be addressed when developing solid-state methods. Method development and validation for pharmaceuticals is Read more
Polymorph screens and salt screens are important components for drug development. The goal of polymorph screening is to try to find all possible crystal forms by small-scale crystallization and to select a stable form that can be manufactured and formulated into a dosage form. Salt screens are commonly used to alter the physicochemical properties of Read more
Improved Pharma, LLC participated in the AAPS PharmSci 360 meeting in San Antonio, TX from Nov 3-6, 2019. The meeting was highly successful and allowed for several discussions surrounding our problem solving strategy. Our booth was ideally located among several formulation companies and the formulation poster sessions, enabling a great forum for gathering scientists Read more
Title: Synchrotron X-Ray Diffraction and Pair Distribution Function Analysis of Drug/Polymer Dispersions: A Comparison of Subtraction Techniques to Isolate Intra- and Intermolecular Interactions Authors: PA Smitha and SR Byrna, GLB de Araujob, CJ Benmorec Affiliations: a) Improved Pharma LLC, b) Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, c) X-ray Science Division, Read more
WEST LAFAYETTE, IND. (PRWEB) JUNE 10, 2019 Improved Pharma LLC announces the publication of “Predictive and Accelerated Formulation Design Using Synchrotron Methods” in the July 2019 issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The authors are Stephen R. Byrn and Pamela A. Smith of Improved Pharma, along with Xiaoming Sean Chen of Read more
Improved Pharma and Excelsus Structural Solutions (Swiss) AG are continuing their collaboration to better enable access to synchrotron facilities for industrial clients, especially for pharmaceutical R&D. At the conference, we discussed recent scientific advances, provided instruction on XRPD and pairwise distribution function (PDF) analysis, and facilitated discussions focused on establishing guidelines for the analysis of Read more
Smith1, C.J. Benmore2, J.K.R. Weber2,3 and S.R. Byrn1. 1) Improved Pharma, West Lafayette, IN 47906, USA 2) X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA 3) Materials Development, Inc., Arlington Heights, IL 60004, USA The kinetics and disorder of hydration (or dehydration) of pharmaceutical hydrates is of the utmost importance Read more
Non-crystalline phases such as amorphous states can lead to increased solubility for drugs. However, amorphous materials are notoriously unstable and tend to crystallize over time. As such, many amorphous materials are created in a dispersion with a polymer to increase their physical stability. X-ray powder diffraction patterns of amorphous materials are broad and not useful Read more
