Improved Pharma, LLC participated in the AAPS PharmSci 360 meeting in San Antonio, TX from Nov 3-6, 2019. The meeting was highly successful and allowed for several discussions surrounding our problem solving strategy. Our booth was ideally located among several formulation companies and the formulation poster sessions, enabling a great forum for gathering scientists Read more
Title: Synchrotron X-Ray Diffraction and Pair Distribution Function Analysis of Drug/Polymer Dispersions: A Comparison of Subtraction Techniques to Isolate Intra- and Intermolecular Interactions Authors: PA Smitha and SR Byrna, GLB de Araujob, CJ Benmorec Affiliations: a) Improved Pharma LLC, b) Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, c) X-ray Science Division, Read more
WEST LAFAYETTE, IND. (PRWEB) JUNE 10, 2019 Improved Pharma LLC announces the publication of “Predictive and Accelerated Formulation Design Using Synchrotron Methods” in the July 2019 issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The authors are Stephen R. Byrn and Pamela A. Smith of Improved Pharma, along with Xiaoming Sean Chen of Read more
Improved Pharma and Excelsus Structural Solutions (Swiss) AG are continuing their collaboration to better enable access to synchrotron facilities for industrial clients, especially for pharmaceutical R&D. At the conference, we discussed recent scientific advances, provided instruction on XRPD and pairwise distribution function (PDF) analysis, and facilitated discussions focused on establishing guidelines for the analysis of Read more
Smith1, C.J. Benmore2, J.K.R. Weber2,3 and S.R. Byrn1. 1) Improved Pharma, West Lafayette, IN 47906, USA 2) X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA 3) Materials Development, Inc., Arlington Heights, IL 60004, USA The kinetics and disorder of hydration (or dehydration) of pharmaceutical hydrates is of the utmost importance Read more
Non-crystalline phases such as amorphous states can lead to increased solubility for drugs. However, amorphous materials are notoriously unstable and tend to crystallize over time. As such, many amorphous materials are created in a dispersion with a polymer to increase their physical stability. X-ray powder diffraction patterns of amorphous materials are broad and not useful Read more
Current approaches to accelerated drug development typically involve parallel track activities utilizing sophisticated project management capabilities. Improved Pharma has developed a strategy that continues to utilize these project management tools but in addition utilizes predictive tools based on structure analysis of formulations and anticipation of major instabilities of formulations by assessing formulation risk. Orphan drugs Read more
Dr. Stephen Byrn and his co-authors have published an updated and thorough textbook focused on solid-state properties of pharmaceutical materials. Building off of his first textbook, Solid-State Chemistry of Drugs, this newest publication brings together solid-state chemistry, key analytical techniques, critical physical attributes, and a strategic approach for selecting and producing the correct form. With Read more
