Additional Research on Bedaquiline Salts recently published in Acta Crystallographica

Improved Pharma is pleased to announce an additional open-source publication describing the structures of Bedaquiline maleate salts that is now available to download.  Previously, our lab was able to identify promising new benzoate salts of Bedaquiline, a first-in-class drug used in the treatment of tuberculosis.  This current publication describes the successfully solved crystal structures obtained from Read more

Additional Research on Bedaquiline Salts recently published in Acta Crystallographica2021-05-03T12:59:14+00:00

Recent research on bedaquiline selected for the November cover of Acta Crystallographic

Improved Pharma is pleased to announce the open-source publication of research into finding new salts of bedaquiline, an important drug for the treatment of tuberculosis. The drug is currently marketed in the US as the fumarate salt. Our team discovered several new salts, and the crystal structures of two benzoate salts are described in this Read more

Recent research on bedaquiline selected for the November cover of Acta Crystallographic2020-12-14T13:52:51+00:00

Improved Pharma presenting at AAPS 2020 PHARMSCI 360 with Rapid Fire Presentation and Poster

WEST LAFAYETTE, IND. (PRWEB) OCTOBER 26, 2020 Interact with us via poster number 924440 and the Advances and Innovation in Formulation Development Rapid Fire session. On Wednesday October 28th, Dr. Pamela Smith, COO of Improved Pharma, will present “Synchrotron-Based Formulation Development” in the Rapid Fire: Formulation and Quality – Chemical session. Those registered for the meeting Read more

Improved Pharma presenting at AAPS 2020 PHARMSCI 360 with Rapid Fire Presentation and Poster2020-10-26T17:34:00+00:00

Published book chapter on Solid-State Characterization

Improved Pharma COO Pamela Smith is co-author of a chapter in the latest edition of Specification of Drug Substances and Products: Development and Validation of Analytical Methods. The chapter, Solid-State Characterization – Method Development and Validation, focuses on the key issues that must be addressed when developing solid-state methods. Method development and validation for pharmaceuticals is Read more

Published book chapter on Solid-State Characterization2020-10-21T15:04:46+00:00

Learn about Improved Pharma’s approach to polymorph and salt screening

Polymorph screens and salt screens are important components for drug development. The goal of polymorph screening is to try to find all possible crystal forms by small-scale crystallization and to select a stable form that can be manufactured and formulated into a dosage form. Salt screens are commonly used to alter the physicochemical properties of Read more

Learn about Improved Pharma’s approach to polymorph and salt screening2020-07-15T20:52:18+00:00

Improved Pharma’s highly successful AAPS meeting and presentation

Improved Pharma, LLC participated in the AAPS PharmSci 360 meeting in San Antonio, TX from Nov 3-6, 2019. The meeting was highly successful and allowed for several discussions surrounding our problem solving strategy.  Our booth was ideally located among several formulation companies and the formulation poster sessions, enabling a great forum for gathering scientists Read more

Improved Pharma’s highly successful AAPS meeting and presentation2020-04-30T19:01:31+00:00

Poster to be presented at 2019 AAPS PharmSci 360 conference

Title: Synchrotron X-Ray Diffraction and Pair Distribution Function Analysis of Drug/Polymer Dispersions: A Comparison of Subtraction Techniques to Isolate Intra- and Intermolecular Interactions Authors: PA Smitha and SR Byrna, GLB de Araujob, CJ Benmorec Affiliations: a) Improved Pharma LLC, b) Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, c) X-ray Science Division, Read more

Poster to be presented at 2019 AAPS PharmSci 360 conference2020-04-30T19:03:18+00:00

Improved Pharma Publishes Review Article in AAPS PharmSciTech

WEST LAFAYETTE, IND. (PRWEB) JUNE 10, 2019 Improved Pharma LLC announces the publication of “Predictive and Accelerated Formulation Design Using Synchrotron Methods” in the July 2019 issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The authors are Stephen R. Byrn and Pamela A. Smith of Improved Pharma, along with Xiaoming Sean Chen of Read more

Improved Pharma Publishes Review Article in AAPS PharmSciTech2020-04-30T19:06:37+00:00

Advances in synchrotron XRPD in the pharmaceutical industry discussed at SPS-XRPD-2 and PPXRD-16

Improved Pharma and Excelsus Structural Solutions (Swiss) AG are continuing their collaboration to better enable access to synchrotron facilities for industrial clients, especially for pharmaceutical R&D.  At the conference, we discussed recent scientific advances, provided instruction on XRPD and pairwise distribution function (PDF) analysis, and facilitated discussions focused on establishing guidelines for the analysis of Read more

Advances in synchrotron XRPD in the pharmaceutical industry discussed at SPS-XRPD-2 and PPXRD-162020-04-30T19:07:13+00:00

Humidity Effects on Amorphous Pharmaceuticals

Smith1, C.J. Benmore2, J.K.R. Weber2,3 and S.R. Byrn1. 1) Improved Pharma, West Lafayette, IN 47906, USA 2) X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA 3) Materials Development, Inc., Arlington Heights, IL 60004, USA The kinetics and disorder of hydration (or dehydration) of pharmaceutical hydrates is of the utmost importance Read more

Humidity Effects on Amorphous Pharmaceuticals2020-04-30T19:08:10+00:00
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