Improved Pharma is pleased to announce that their ritonavir research with Varda Space Industries that was published earlier this year has been selected by Organic Process Research & Development as one of the top “remarkable accomplishments from the scientific literature that are expected to be relevant and important with future practical applications”. A brief summary of the work, along with other highlighted Read more
Pharmaceutical materials can exist in a crystalline or amorphous state. Figure 1 illustrates the crystalline state as a perfectly ordered solid with molecules (circles) packed in an orderly array. Figure 1 also illustrates an amorphous material as a disordered material with only short-range order. Crystalline materials give an X-ray diffraction pattern because Bragg planes Read more
WEST LAFAYETTE, IND. (PRWEB) APRIL 04, 2023 Improved Pharma is pleased to announce the return of this popular and informative workshop. Registration and additional information can be found here: SPS-XRPD Workshop Over 20 guest lecturers have been gathered to present on the following topics: Regulatory aspects Role of polymorphism in intellectual property rights Synchrotron advanced instrumentation and applications in Read more
WEST LAFAYETTE, IND. (PRWEB) MARCH 21, 2023 Improved Pharma will be at the ACS Spring 2023 National Meeting to be held in Indianapolis March 26 – 30, 2023. There are two opportunities to interact with Improved Pharma at this event. On Monday March 27th is the reception is for the Chemistry and Law Division of ACS, whose purpose Read more
Since the ritonavir crisis in 1998, when a lifesaving HIV protease inhibitor had to be withdrawn from the market for almost a year due to a sudden and unpredictable appearance of a new less soluble polymorph, ritonavir has been of interest to solid state chemists, crystallographers, and drug development scientists.[1-4] After the appearance of Form Read more
In the early 1990’s SSCI, Inc. began working with Parke-Davis Warner-Lambert by providing X-ray diffraction measurements on samples manufactured at its Holland, Michigan manufacturing facility. One of the compounds under investigation was atorvastatin calcium. Atorvastatin had been synthesized by Bruce Roth at Warner-Lambert and patented in 1987 (US Patent 4,681,893). It was under development as Read more
Improved Pharma is pleased to announce the return of this very popular and informative workshop. Following previous workshops held at Purdue in 2018 and the Paul Scherrer Institute in Switzerland in 2019, the workshop returns to Purdue for 2023. Attendees can network with solid-state experts from around the world, learn how synchrotron-XRPD can be used Read more
To enhance the solubility of orally administered pharmaceuticals, liquid capsules or amorphous tablets are often preferred over crystalline drug products. However, little is known regarding the variation in bonding mechanisms between pharmaceutical molecules in their different disordered forms. In this study, liquid and melt-quenched glassy carbamazepine have been studied using high energy X-ray diffraction and Read more
WEST LAFAYETTE, IND. (PRWEB) NOVEMBER 21, 2022 Improved Pharma is pleased to announce a new collaboration with Chyall Pharmaceutical Consulting, LLC (dba “Chyall Pharma”) enabling expansion of expertise and service offerings to the pharmaceutical industry in support of drug substance and drug product development. Chyall Pharma’s founder and President Dr. Leonard (“Len”) Chyall will serve as Read more
On Monday, November 14, Dr. Dale K. Purcell, President of Chemical Microscopy and consultant with Improved Pharma, will present an invited speaker “Unsafe Pharmaceuticals: Fake or Counterfeit” in the POWERHOUSE SESSION: Challenges of Counterfeit Detection in Pharmaceutical Industry. The need to combat counterfeiting pharmaceutical drugs, the pharmaceutical packaging sector has largely implemented advanced package labeling Read more
