Since the ritonavir crisis in 1998, when a lifesaving HIV protease inhibitor had to be withdrawn from the market for almost a year due to a sudden and unpredictable appearance of a new less soluble polymorph, ritonavir has been of interest to solid state chemists, crystallographers, and drug development scientists.[1-4] After the appearance of Form Read more
In the early 1990’s SSCI, Inc. began working with Parke-Davis Warner-Lambert by providing X-ray diffraction measurements on samples manufactured at its Holland, Michigan manufacturing facility. One of the compounds under investigation was atorvastatin calcium. Atorvastatin had been synthesized by Bruce Roth at Warner-Lambert and patented in 1987 (US Patent 4,681,893). It was under development as Read more
Improved Pharma is pleased to announce the return of this very popular and informative workshop. Following previous workshops held at Purdue in 2018 and the Paul Scherrer Institute in Switzerland in 2019, the workshop returns to Purdue for 2023. Attendees can network with solid-state experts from around the world, learn how synchrotron-XRPD can be used Read more
To enhance the solubility of orally administered pharmaceuticals, liquid capsules or amorphous tablets are often preferred over crystalline drug products. However, little is known regarding the variation in bonding mechanisms between pharmaceutical molecules in their different disordered forms. In this study, liquid and melt-quenched glassy carbamazepine have been studied using high energy X-ray diffraction and Read more
WEST LAFAYETTE, IND. (PRWEB) NOVEMBER 21, 2022 Improved Pharma is pleased to announce a new collaboration with Chyall Pharmaceutical Consulting, LLC (dba “Chyall Pharma”) enabling expansion of expertise and service offerings to the pharmaceutical industry in support of drug substance and drug product development. Chyall Pharma’s founder and President Dr. Leonard (“Len”) Chyall will serve as Read more
On Monday, November 14, Dr. Dale K. Purcell, President of Chemical Microscopy and consultant with Improved Pharma, will present an invited speaker “Unsafe Pharmaceuticals: Fake or Counterfeit” in the POWERHOUSE SESSION: Challenges of Counterfeit Detection in Pharmaceutical Industry. The need to combat counterfeiting pharmaceutical drugs, the pharmaceutical packaging sector has largely implemented advanced package labeling Read more
WEST LAFAYETTE, IND. (PRWEB) SEPTEMBER 27, 2022 Improved Pharma is presenting their research on all three days of the AAPS conference. On Monday October 17th at 2:30 pm, please visit monitor #31 in forum 6. Ms. Ruba Alajlouni will present “Feasibility of Synchrotron XRD for the analysis of mixture sub-samples.” She will share results demonstrating the effective Read more
DEA registration allows Improved Pharma to support pharmaceutical development for all types of controlled substances. WEST LAFAYETTE, IND. (PRWEB) SEPTEMBER 19, 2022 Improved Pharma is pleased to announce their DEA registration for schedules I – V. The new controlled substance license enhances the wide variety of drug substances and drug products that can now be Read more
WEST LAFAYETTE, Ind. (PRWEB)September 13, 2022 Developing new tools and advancing pharmaceutical development is a key part of Improved Pharma’s mission. In 2021, Improved Pharma had the unique opportunity to start polymorph screening research projects in close collaboration with Varda Space Industries with the intent of advancing pharmaceutical product manufacturing. As a result, the Read more
Crystals were observed growing within a DayQuil Liquicap. This blog post describes the approach taken to isolate and identify the unknown crystals. Vicks® DayQuil™ Severe Cold & Flu provides an over the counter non-drowsy, daytime relief for common cold and flu symptoms. DayQuil™ Severe is formulated to relieve or reduce headache, fever, sore throat, Read more
