At AAPS PharmSci 360 it was clear that new excipients could be utilized to innovatively solve a range of amorphous dispersion/formulation problems. These new excipients provide significant strategy advances over conventional approaches and although our Improved Pharma scientists utilized a number of novel approaches to prepare amorphous dispersions while at SSCI, these new excipients provide Read more
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Improved Pharma, LLC participated in the AAPS PharmSci 360 meeting in San Antonio, TX from Nov 3-6, 2019. The meeting was highly successful and allowed for several discussions surrounding our problem solving strategy. Our booth was ideally located among several formulation companies and the formulation poster sessions, enabling a great forum for gathering scientists Read more
WEST LAFAYETTE, IND. (PRWEB) SEPTEMBER 24, 2019 Improved Pharma LLC will be presenting their latest research in the area of high-level X-ray methods using synchrotron-produced X-rays to study amorphous drug formulations. On Monday, November 4th, Dr. Pamela Smith, COO of Improved Pharma, will present “Synchrotron X-Ray Diffraction and Pair Distribution Function Analysis of Drug/Polymer Dispersions: A Read more
Title: Synchrotron X-Ray Diffraction and Pair Distribution Function Analysis of Drug/Polymer Dispersions: A Comparison of Subtraction Techniques to Isolate Intra- and Intermolecular Interactions Authors: PA Smitha and SR Byrna, GLB de Araujob, CJ Benmorec Affiliations: a) Improved Pharma LLC, b) Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, c) X-ray Science Division, Read more
WEST LAFAYETTE, IND. (PRWEB) AUGUST 29, 2019 Prof. Stephen R. Byrn travels to Africa several times a year to teach in the Sustainable Medicines in Africa program, which includes a master’s degree in biotechnology innovation and regulatory science. The next course will take place in Arusha, Tanzania September 2nd through 13th, 2019. Topics to be Read more
WEST LAFAYETTE, IND. (PRWEB) JULY 19, 2019 Improved Pharma LLC announces the upcoming presentation of “Continuity of Solids between Amorphous and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. The authors are Stephen R. Byrn and Pamela A. Smith of Improved Pharma, along with Chris Benmore of Argonne National Laboratory and Gabriel de Read more
DOWNLOAD THIS WHITE PAPER AS A PDF BY CLICKING ON THIS LINK The abuse and misuse of prescription opioid products is a serious and growing public health problem. Opioid products are often manipulated to bypass extended-release (ER) properties. As such, the FDA is encouraging the development of opioid formulations that are more difficult to abuse Read more
WEST LAFAYETTE, IND. (PRWEB) JUNE 10, 2019 Improved Pharma LLC announces the publication of “Predictive and Accelerated Formulation Design Using Synchrotron Methods” in the July 2019 issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The authors are Stephen R. Byrn and Pamela A. Smith of Improved Pharma, along with Xiaoming Sean Chen of Read more
Improved Pharma and Excelsus Structural Solutions (Swiss) AG are continuing their collaboration to better enable access to synchrotron facilities for industrial clients, especially for pharmaceutical R&D. At the conference, we discussed recent scientific advances, provided instruction on XRPD and pairwise distribution function (PDF) analysis, and facilitated discussions focused on establishing guidelines for the analysis of Read more
Smith1, C.J. Benmore2, J.K.R. Weber2,3 and S.R. Byrn1. 1) Improved Pharma, West Lafayette, IN 47906, USA 2) X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA 3) Materials Development, Inc., Arlington Heights, IL 60004, USA The kinetics and disorder of hydration (or dehydration) of pharmaceutical hydrates is of the utmost importance Read more