Part 3 of 3 | Improved Pharma peptide crystallization series by Stephen R. Byrn. Ph.D. Crystalline peptide medicines extend well beyond insulin. Some marketed molecules have solved structures of the isolated drug; others have Read more
Part 2 of 3 | Improved Pharma peptide crystallization series by Stephen R. Byrn. Ph.D. Insulin and GLP-1 receptor agonists belong in the same conversation about peptide medicines, but their crystallization histories are very Read more
Part 1 of 3 | Improved Pharma peptide crystallization series by Stephen R. Byrn Peptide medicines have moved far beyond insulin. They now include treatments for metabolic, endocrine, gastrointestinal, and other diseases. Yet for Read more
Stephen Byrn, Pamela Smith, David Engers Comparability intended to describe the sameness of amorphous materials can be assessed in a scientifically and pharmaceutically meaningful way. More specifically, it addresses how amorphous drug substances or Read more
Stephen Byrn, David Engers, Pamela Smith In the modern landscape of pharmaceutical development, it is increasingly understood that a medicine is more than just a molecule because the solid form of an active pharmaceutical Read more
Steve Byrn and David Engers Improved Pharma Feb. 11, 2026 Improved Pharma has recently expanded its dissolution capabilities by installing a fully automated Agilent 708-DS dissolution apparatus paired with the 850-DS autosampler. This capability Read more
Authors Jared Smit, David Engers, Steve Byrn In modern small-molecule development, solid-state characterization is far more than a routine analytical task.(Byrn, Zografi et al. 2025) It defines the manufacturable form of an API, supports Read more
Single-crystal X-ray diffraction (SCXRD) provides the most definitive structural picture of pharmaceutical solids. From a single crystal, we obtain the unit cell, space group, and full atomic coordinates, which reveal hydrogen-bonding networks, π–π (ring) Read more
Steve Byrn, September 26, 2025 Reduced dose formulations provide one of the most exciting approaches to improving medicines by reducing side effects, pill burden, and drug load in the patient and by reducing cost Read more
Solid State Chemistry of Long-Acting Injectable Suspensions Steve Byrn September 1, 2025 The Enduring Impact of Long-Acting Injectable Suspensions in Medicine Long-acting injectable (LAI) suspensions play a crucial role in modern drug delivery, offering Read more
