Single-crystal X-ray diffraction (SCXRD) provides the most definitive structural picture of pharmaceutical solids. From a single crystal, we obtain the unit cell, space group, and full atomic coordinates, which reveal hydrogen-bonding networks, π–π (ring) Read more
Steve Byrn, September 26, 2025 Reduced dose formulations provide one of the most exciting approaches to improving medicines by reducing side effects, pill burden, and drug load in the patient and by reducing cost Read more
Solid State Chemistry of Long-Acting Injectable Suspensions Steve Byrn September 1, 2025 The Enduring Impact of Long-Acting Injectable Suspensions in Medicine Long-acting injectable (LAI) suspensions play a crucial role in modern drug delivery, offering Read more
In our last blog, we explored the importance of control strategies during early pharmaceutical development. However, two additional elements critical to early-stage Investigational New Drug (IND) applications deserve special attention: process validation and method Read more
Achieving control is essential in early-stage pharmaceutical development, not only to meet regulatory expectations but to ensure consistency, high-quality, and reliability of clinical batches. Improved Pharma has developed a comprehensive control strategy that supports Read more
This blog series will address regulatory problem-solving. Our expertise spans preclinical to market, supporting regulatory submissions, application reviews, and post-approval changes (PAC). Our senior experts have over 200 years of combined experience, including service Read more
Dr. Chris Benmore of Argonne National Laboratory delivered an insightful talk at the 4th Spring Pharmaceutical Synchrotron X-Ray Powder Diffraction Workshop held June 10-11, 2024, at the Novartis campus in Basel, Switzerland. His presentation Read more
The 4th Spring Pharmaceutical Synchrotron X-Ray Powder Diffraction Workshop was held June 10-11, 2024, at the Novartis campus in Basel, Switzerland. The SPS-XRPD workshops are a collaborative effort between Excelsus Structural Solutions in Switzerland Read more
This blog focuses on how microscopy, hot-stage microscopy, and DSC microscopy can be used to develop co-processing strategies and relies heavily on input from Chemical Microscopy LLC, which is closely linked to Improved Pharma. Read more
Our first blog post on co-processed pharmaceutical solids provided a general introduction. A second blog discussed an approach to screening for co-processed pharmaceutical solids. This third blog focuses on analytical methods for studying co-processed Read more
