Improved Pharma at AAPS with Rapid Fire Presentation, Poster, and Booth

Improved Pharma LLC will be presenting their latest research in the area of high-level X-ray methods using synchrotron-produced X-rays to study amorphous drug formulations. On Monday, November 4th, Dr. Pamela Smith, COO of Improved Pharma, will present “Synchrotron X-Ray Diffraction and Pair Distribution Function Analysis of Drug/Polymer Dispersions: A Comparison of Subtraction Techniques to Isolate Intra- and Intermolecular Interactions”. The poster will be presented from 11:30 AM to 12:30 PM in Poster Forum 6. The full abstract of the poster can be accessed here.

On Tuesday, November 5th, Dr. Smith will present “Synchrotron X-ray Analysis of Amorphous Drugs and Drug:Polymer Dispersions” in the Rapid Fire: Formulation and Quality – Chemical session. The session takes place in Exhibit Hall 234 from 3:00 PM to 5:00 PM. Much of our research focuses on using synchrotron X-ray Pair Distribution Function (SXPDF) techniques to probe atom-atom distances in amorphous materials and dispersions. Not all amorphous materials are equivalent, and the PDF patterns reflect the degree of disorder in the materials. SXPDF can provide important regulatory information regarding the sameness of various formulations or lots prepared using different techniques (e.g. spray drying and melt extrusion). SXPDF can also detect neighboring drug molecules in a drug-polymer dispersion. If present, the dispersion is more likely to crystallize as compared to dispersions where no drug domains are detected. This information is extremely important, especially when assessing the risk of a formulation undergoing unwanted changes during manufacturing, scale-up, or storage. SXPDF can also help guide improved formulations of existing products, extending intellectual property protections.

Improved Pharma will be exhibiting in booth 551, conveniently located in the Formulation and Quality section next to Poster Forum 2. We look forward to meeting with you to discuss the latest advances in pharmaceutical research and development. Have a problem with solubility or bioavailability? Want to reformulate your drug product? Looking for assistance with patent litigation? Or, do you just need some analytical testing services? Feel free to stop by to see if we can help you. If you’d like to book an appointment or have a discussion prior to the meeting, please contact us at info@improvedpharma.com.

Stephen Byrn, CSO of Improved Pharma, has a long history associated with the AAPS meeting and was featured as the Member Spotlight of the August 2019 issue of AAPS News Magazine. You can read the article here. As noted in the article, Byrn successfully launched his first business (SSCI) through AAPS. He stated: “My wife and I started our company with only two people. We purchased the AAPS mailing list and taught short courses, both on our own and through AAPS. After we opened our lab, we rented a 10-foot by 10-foot booth near the posters, and I stood in the walkway and told people why they needed our services since we were a research and information company. We eventually grew to 100 employees and sold the company in 2006. Some of the funds from the sale helped fund our work in Africa, especially in the early days. Now we’ve started a new research and information company called Improved Pharma. Although a lot of things have changed since we started our first company, we are still going to rent a 10-foot by 10-foot booth near the posters at this year’s AAPS meeting and start the process all over again.”

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2019-10-09T21:26:03+00:00