Latest Publications
Seeing Solids Clearly—Beyond Powder Patterns with Single-Crystal X-ray Diffraction for Polymorphs, Hydrates, and IP Confidence: How Improved Pharma Uses SCXRD
Single-crystal X-ray diffraction (SCXRD) provides the most definitive structural picture of pharmaceutical solids. From a single crystal, we obtain the unit cell, space group, and full atomic coordinates, which reveal hydrogen-bonding networks, π–π (ring)Read more
Reduced Dose Formulations
Steve Byrn, September 26, 2025 Reduced dose formulations provide one of the most exciting approaches to improving medicines by reducing side effects, pill burden, and drug load in the patient and by reducing costRead more
Solid State Chemistry of Long-Acting Injectable Suspensions
Solid State Chemistry of Long-Acting Injectable Suspensions Steve Byrn September 1, 2025 The Enduring Impact of Long-Acting Injectable Suspensions in Medicine Long-acting injectable (LAI) suspensions play a crucial role in modern drug delivery, offeringRead more
Process and Method Validation in IND Drug Development: Building a Robust Foundation
In our last blog, we explored the importance of control strategies during early pharmaceutical development. However, two additional elements critical to early-stage Investigational New Drug (IND) applications deserve special attention: process validation and methodRead more
Improved Pharma Expands In-House Single Crystal Capabilities
Addition of crystallographer and new instrumentation in support of single crystal structure determination WEST LAFAYETTE, Ind., July 22, 2025 /PRNewswire/ -- Improved Pharma has expanded its capabilities to include in-house single crystal structure determination with the recent acquisitionRead more
Improved Pharma initiates research and development program
Improved Pharma is investing in an internal R&D program focused on solid lipid nanoparticles (SLNs). A recent expansion of their research facility included resources dedicated to this endeavor. WEST LAFAYETTE, Ind., July 1, 2025 /PRNewswire/ -- SLNs are a typeRead more