Dr. Chris Benmore of Argonne National Laboratory delivered an insightful talk at the 4th Spring Pharmaceutical Synchrotron X-Ray Powder Diffraction Workshop held June 10-11, 2024, at the Novartis campus in Basel, Switzerland. His presentation Read more
The 4th Spring Pharmaceutical Synchrotron X-Ray Powder Diffraction Workshop was held June 10-11, 2024, at the Novartis campus in Basel, Switzerland. The SPS-XRPD workshops are a collaborative effort between Excelsus Structural Solutions in Switzerland Read more
This blog focuses on how microscopy, hot-stage microscopy, and DSC microscopy can be used to develop co-processing strategies and relies heavily on input from Chemical Microscopy LLC, which is closely linked to Improved Pharma. Read more
Our first blog post on co-processed pharmaceutical solids provided a general introduction. A second blog discussed an approach to screening for co-processed pharmaceutical solids. This third blog focuses on analytical methods for studying co-processed Read more
Co-processed pharmaceutical solids are of considerable interest because of the improvements co-processing can make in a number of solid state properties and pharmaceutical processes. Our first blog on this topic provided a general introduction Read more
Co-processed pharmaceutical solids are rising to the forefront as an important concept in pharmaceutical development. This general introduction is the first in a planned series of blogs delving into this exciting area. Schenck and Read more
DSC is a powerful method for the analysis of a range of materials. A typical DSC experiment measures the heat changes that occur within the sample when the temperature is changed. For the analysis, Read more
Pharmaceutical materials can exist in a crystalline or amorphous state. Figure 1 illustrates the crystalline state as a perfectly ordered solid with molecules (circles) packed in an orderly array. Figure 1 also illustrates an Read more
Since the ritonavir crisis in 1998, when a lifesaving HIV protease inhibitor had to be withdrawn from the market for almost a year due to a sudden and unpredictable appearance of a new less soluble Read more
In the early 1990’s SSCI, Inc. began working with Parke-Davis Warner-Lambert by providing X-ray diffraction measurements on samples manufactured at its Holland, Michigan manufacturing facility. One of the compounds under investigation was atorvastatin calcium. Atorvastatin Read more
