Structure of Amorphous Materials – Structure Determination Service

One of the most critical parts of drug discovery and development is identifying the structure of the drug substance and drug product. For crystalline materials and biologicals it is routine to determine the arrangement of covalent bonds in the drug substance and drug product and the structure of the solid forms of the drug substance. Read more

Structure of Amorphous Materials – Structure Determination Service2019-03-06T15:19:53+00:00

AAPS Poster

Non-crystalline phases such as amorphous states can lead to increased solubility for drugs.  However, amorphous materials are notoriously unstable and tend to crystallize over time.  As such, many amorphous materials are created in a dispersion with a polymer to increase their physical stability.  X-ray powder diffraction patterns of amorphous materials are broad and not useful Read more

AAPS Poster2019-01-25T21:42:56+00:00

Drug Delivery Device Summit Presentation

Current approaches to accelerated drug development typically involve parallel track activities utilizing sophisticated project management capabilities.  Improved Pharma has developed a strategy that continues to utilize these project management tools but in addition utilizes predictive tools based on structure analysis of formulations and anticipation of major instabilities of formulations by assessing formulation risk.  Orphan drugs Read more

Drug Delivery Device Summit Presentation2019-03-06T15:39:33+00:00

Book: Solid State Properties of Pharmaceutical Materials

Dr. Stephen Byrn and his co-authors have published an updated and thorough textbook focused on solid-state properties of pharmaceutical materials.  Building off of his first textbook, Solid-State Chemistry of Drugs, this newest publication brings together solid-state chemistry, key analytical techniques, critical physical attributes, and a strategic approach for selecting and producing the correct form.  With Read more

Book: Solid State Properties of Pharmaceutical Materials2019-01-21T23:16:18+00:00